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Cancer and microbiome-targeted therapies
Avtar S Meena1, Pratibha Singh2, Pradeep K Shukla3
1Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
International Review of Cell and Molecular Biology
|July 13, 2025
Summary
The microbiome significantly impacts cancer development and treatment response. Targeting gut bacteria with therapies like probiotics offers new ways to improve cancer care and reduce side effects.
Area of Science:
- Oncology
- Microbiome Research
- Immunology
Background:
- The human microbiome plays a critical role in health and disease.
- Emerging evidence links the microbiome to cancer development, progression, and treatment outcomes.
- Understanding this interplay is crucial for novel therapeutic strategies.
Purpose of the Study:
- To review the influence of the microbiome on cancer.
- To explore microbiome-targeted therapies in oncology.
- To discuss challenges and future directions in this field.
Main Methods:
- Literature review of current research on the microbiome and cancer.
- Analysis of mechanisms by which microbes affect tumorigenesis and therapy.
- Examination of microbiome modulation strategies.
Main Results:
- Microbial communities influence immune responses, drug metabolism, and the tumor microenvironment.
- The microbiome can both promote and inhibit cancer development.
- Microbiome modulation strategies show potential in enhancing cancer therapy efficacy and reducing side effects.
Conclusions:
- The microbiome is a key factor in cancer biology and treatment.
- Microbiome-targeted therapies offer promising avenues for personalized cancer care.
- Further research is needed to integrate these approaches into clinical practice.
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