Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuronal interactions during epileptic events in vitro.

R D Traub, R K Wong, R Miles

    Federation Proceedings
    |December 1, 1985
    PubMed
    Summary

    Convulsant agents like penicillin block synaptic inhibition, causing synchronized neuronal bursts in brain slices. This experimental model helps study epilepsy by mimicking key features of epileptic events.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Pictorial review of the use of percutaneous mechanical thromboaspiration in peripheral vascular occlusions.

    Clinical radiology·2025
    Same author

    Centaur 29P/Schwassmann-Wachmann 1 and its near-nucleus environment from a stellar occultation.

    Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2025
    Same author

    A pilot program to improve TB care with primary and specialty care coordination in TB public health clinic.

    IJTLD open·2024
    Same author

    Communication breakdown between physicians and IBS sufferers: what is the conundrum and how to overcome it?

    The journal of the Royal College of Physicians of Edinburgh·2017
    Same author

    Unbalanced Peptidergic Inhibition in Superficial Neocortex Underlies Spike and Wave Seizure Activity.

    The Journal of neuroscience : the official journal of the Society for Neuroscience·2015
    Same author

    Are auras a reliable clinical indicator in medial temporal lobe epilepsy with hippocampal sclerosis?

    European journal of neurology·2015

    Area of Science:

    • Neuroscience
    • Epilepsy research
    • In vitro electrophysiology

    Background:

    • Epileptic events in vitro are induced by convulsant agents.
    • These events involve synchronized neuronal bursts.
    • The mechanism involves blocking synaptic inhibition.

    Purpose of the Study:

    • To investigate the generation of synchronized neuronal bursts.
    • To understand the role of synaptic inhibition blockade in epilepsy.
    • To utilize an in vitro model for studying epileptic phenomena.

    Main Methods:

    • Perfusion of in vitro brain slices with convulsant agents (penicillin, picrotoxin).
    • Electrophysiological recording to observe neuronal activity.
    • Analysis of synchronized neuronal bursting patterns.

    Main Results:

    • Convulsant agents successfully induced synchronized neuronal bursts.
    • Blockade of synaptic inhibition was confirmed as the cause.
    • The hippocampus network's sparse excitatory interconnections were key for synchronization.

    Conclusions:

    • In vitro brain slices treated with convulsants provide a model for studying epilepsy.
    • Synaptic inhibition blockade is critical for generating synchronized epileptic events.
    • Hippocampal network properties facilitate neuronal synchronization leading to bursting.

    Related Experiment Videos