Localized Morphea in a Pediatric Patient Successfully Treated With Topical Ruxolitinib

Area of Science:

• Dermatology
• Pediatric Rheumatology
• Fibrotic Skin Disorders

Background:

• Pediatric morphea involves skin and underlying tissue fibrosis.
• High-potency topical steroids are standard for uncomplicated localized disease.
• Limited data exists for treating localized recalcitrant pediatric morphea.

Observation:

• A 17-year-old female presented with biopsy-confirmed morphea.
• Previous treatment with clobetasol ointment was ineffective.
• The patient had localized, recalcitrant disease.

Findings:

• Topical ruxolitinib 1.5% cream combined with intralesional triamcinolone yielded significant clinical improvement.
• This combination therapy was successful where topical steroids failed.

Implications:

• Topical ruxolitinib and intralesional triamcinolone represent a promising treatment option for recalcitrant pediatric morphea.
• This case expands therapeutic options for a rare pediatric fibrotic condition.
• Further research is warranted to validate these findings in larger cohorts.