Related Experiment Video
Updated: Sep 15, 2025

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
Published on: July 19, 2024
Malvidin-3-O-glucoside and Malvidin-3,5-O-diglucoside Alleviate Glycolipid Metabolic Disorder by Modulating Pancreas
Wenxiu Yue1, Zhenan Shi1, Luye Yang1
1College of Enology, Northwest A&F University, Yangling 712100, Shaanxi, China.
Abstract:
The anthocyanins malvidin-3-O-glucoside (M3G) and malvidin-3,5-O-diglucoside (M35G) were purified from the grape varieties Vitis vinifera L. and Vitis davidii Foex peels, respectively, and their effects on glycolipid metabolic disorders (GLMDs) were investigated using a mouse model. Mice treated with M3G or M35G showed controlled body weight, preservation of normal histomorphological features and islet size of the pancreas, and amelioration of hyperglycemia and insulin resistance induced by a high-fructose diet. M35G was more effective than M3G in improving insulin sensitivity, lipid homeostasis, and adipocyte hypertrophy. Moreover, M3G and M35G regulated hepatic genes (e.g., ketohexokinase, phosphoenolpyruvate carboxykinase, fatty acid synthase, and carbohydrate response element binding protein-beta) to restrain GLMD development. Furthermore, the inhibition of hepatic inflammation and oxidative stress and the modulation of the abundance of probiotic microbial genera synergistically improved physiological indices and prevented GLMD development.
More Related Videos
Related Concept Videos
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are...
Overview of Carbohydrate Metabolism
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose Transporters
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Dipeptidyl Peptidase 4 Inhibitors
Oral Hypoglycemic Agents: Glinides
Oral Hypoglycemic Agents: Biguanides and Glitazones

