Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

Cardiomyopathy VII: Pre and Post Operative Nursing Management

29
Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
29
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

54
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
54
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

37
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
37
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

24
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
24
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

1.5K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.5K
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

36
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
36

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Acoramidis on Kidney Function in Transthyretin Amyloid Cardiomyopathy.

Circulation. Heart failure·2026
Same author

Multicenter cohort analysis of cardiac amyloidosis patients treated with heart transplant.

Revista espanola de cardiologia (English ed.)·2026
Same author

Real-world burden of hypertrophic cardiomyopathy on healthcare use and health-related quality of life in Italy, Spain, and the United States.

Journal of medical economics·2026
Same author

Outpatient worsening heart failure in transthyretin amyloid cardiomyopathy: Findings from ATTRibute-CM.

European journal of heart failure·2026
Same author

Baseline characteristics of patients with transthyretin amyloidosis with cardiomyopathy in the CARDIO-TTRansform trial of eplontersen.

European journal of heart failure·2026
Same author

Rationale and Design of CARDIO-TTRansform, a Phase 3 Trial of Eplontersen in Transthyretin Amyloid Cardiomyopathy.

Circulation. Heart failure·2026

Related Experiment Video

Updated: Sep 15, 2025

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples
14:39

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples

Published on: April 21, 2014

17.5K

Cardiovascular Hospitalizations Burden Following Septal Myectomy for Obstructive Hypertrophic Cardiomyopathy.

Ahmed Altibi1,2, Miriam Elman3, Hailey Volk1

  • 1Hypertrophic Cardiomyopathy Center, Division of Cardiology Knight Cardiovascular Institute, Oregon Health and Science University Portland OR USA.

Journal of the American Heart Association
|July 14, 2025
PubMed
Summary

Septal myectomy for obstructive hypertrophic cardiomyopathy leads to significant cardiovascular hospitalizations long-term. Further research is needed to reduce these nonfatal complications and improve patient care.

Keywords:
atrial fibrillationcardiovascular hospitalizationhypertrophic cardiomyopathyseptal myectomy

More Related Videos

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
09:12

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery

Published on: March 27, 2018

9.6K
Cox-Maze IV Procedure Concomitant with Valvular Surgery In Situs Inversus Dextrocardia: A Single-Center Experience in China
08:42

Cox-Maze IV Procedure Concomitant with Valvular Surgery In Situs Inversus Dextrocardia: A Single-Center Experience in China

Published on: February 11, 2022

3.6K

Related Experiment Videos

Last Updated: Sep 15, 2025

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples
14:39

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples

Published on: April 21, 2014

17.5K
Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
09:12

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery

Published on: March 27, 2018

9.6K
Cox-Maze IV Procedure Concomitant with Valvular Surgery In Situs Inversus Dextrocardia: A Single-Center Experience in China
08:42

Cox-Maze IV Procedure Concomitant with Valvular Surgery In Situs Inversus Dextrocardia: A Single-Center Experience in China

Published on: February 11, 2022

3.6K

Area of Science:

  • Cardiology
  • Cardiovascular Surgery
  • Health Outcomes Research

Background:

  • Long-term morbidity after septal myectomy (SM) for obstructive hypertrophic cardiomyopathy (oHCM) is not well-established nationally.
  • Previous studies have not fully characterized the nonfatal outcomes following SM.
  • This study utilizes a national claims database to investigate longer-term post-SM outcomes.

Purpose of the Study:

  • To investigate the incidence and types of nonfatal cardiovascular hospitalizations (CVH) occurring more than 30 days after septal myectomy in adult patients with obstructive hypertrophic cardiomyopathy.
  • To identify predictors associated with increased risk of CVH post-SM.
  • To provide insights into the longer-term burden of morbidity after SM for oHCM.

Main Methods:

  • Analysis of the Symphony Health Claims database (2016-2021) including adult patients with oHCM who underwent SM.
  • Inclusion criteria required at least one claim within 120 days prior to SM.
  • Primary outcome defined as cardiovascular hospitalizations (CVH) occurring >30 days post-SM, with a median follow-up of 2.7 years.

Main Results:

  • A total of 5,324 patients underwent SM, with 95.8% followed for >30 days post-procedure.
  • During follow-up, 46.7% of patients experienced CVH, with 80% occurring within 16 months of SM.
  • Common CVH causes included new atrial fibrillation/flutter (25.4%), ventricular arrhythmias (9.7%), and syncope (9.3%). Baseline predictors for CVH included ICD (aOR 1.72), COPD (aOR 1.65), and CKD (aOR 1.45).

Conclusions:

  • Septal myectomy for obstructive hypertrophic cardiomyopathy is associated with a substantial burden of cardiovascular hospitalizations in the intermediate and long term.
  • Key predictors of post-SM CVH include pre-existing conditions like COPD and CKD, and baseline device implantation.
  • Further investigation into the drivers of these events and mitigation strategies is crucial for improving long-term care for oHCM patients.