LINKING MULTI-SCALE BRAIN CONNECTIVITY WITH VIGILANCE, WORKING MEMORY, AND BEHAVIOR IN ADOLESCENTS.
Prerana Bajracharya1,2, Ram Ballem1,2, Jiayu Chen1,2
1Tri-Institutional Center for Translational Research in Neuroimaging and Data Science, Atlanta, USA.
Biorxiv : the Preprint Server for Biology
|July 14, 2025
Summary
This study reveals a specific brain connectivity pattern in adolescents that is linked to attention, working memory, and behavioral regulation. This finding may help identify neurodevelopmental disorders like ADHD.
Area of Science:
- Neuroscience
- Developmental Psychology
- Medical Imaging
Background:
- Adolescent brain development involves complex changes in intrinsic connectivity networks (ICNs).
- Understanding ICNs is crucial for identifying neurodevelopmental disorders affecting cognitive and behavioral functions.
Purpose of the Study:
- To investigate the relationship between multi-scale ICNs and cognitive/behavioral functions in adolescents.
- To identify potential neuroimaging markers for attention, working memory, and behavioral regulation.
Main Methods:
- Utilized the NeuroMark 2.2 multi-scale ICN template and resting-state fMRI data from the ABCD Study.
- Focused on the fronto-thalamo-cerebellar (FTC) circuitry, including Cerebellar (CB), Subcortical - Extended Thalamic (SC-ET), Higher Cognition - Insular Temporal (HC-IT), and Higher Cognition - Frontal (HC-FR) subdomains.
- Employed principal component analysis (PCA) and canonical correlation analysis (CCA) to examine associations.
Main Results:
- Significant associations were found between multi-scale ICNs and cognitive-behavioral outcomes.
- A specific canonical component linked ICNs to attention, working memory, and behavioral regulation in both discovery and replication datasets.
Conclusions:
- The identified connectivity pattern may serve as a potential biomarker for attention, working memory, and behavioral regulation.
- These findings offer insights into neurodevelopmental disorders, including Attention-Deficit/Hyperactivity Disorder (ADHD).
Keywords:
ABCDCCAFNCPCAbehaviorfronto-thalamo-cerebellar (FTC) circuitrymulti-scale ICNsvigilanceworking memoryMore Related Videos
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