Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Retrovirus Life Cycles01:10

Retrovirus Life Cycles

46.9K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
46.9K
Clinical Trials: Overview01:11

Clinical Trials: Overview

3.4K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
3.4K
Preclinical Development: Overview01:28

Preclinical Development: Overview

4.9K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
4.9K
Drug Discovery: Overview01:26

Drug Discovery: Overview

8.8K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
8.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plazomicin susceptibility profile in carbapenem-resistant Enterobacterales (CRE): a laboratory-based cross-sectional study from a tertiary care hospital in North India.

Indian journal of medical microbiology·2026
Same author

Prevalence and serotype analysis of Diarrhoeagenic Escherichia coli in children less than 10 years at a tertiary hospital in New Delhi, India.

Indian journal of medical microbiology·2026
Same author

Non-O157 diarrheagenic Escherichia coli causing hemolytic uremic syndrome in a child: An emerging paradigm.

Indian journal of medical microbiology·2026
Same author

A rare case of Streptococcus pneumoniae infection in a giant pancreatic pseudocyst.

Indian journal of medical microbiology·2026
Same author

Clonal relationship among Acinetobacter baumannii isolates from different clinical specimens by ERIC-PCR.

Infection, disease & health·2026
Same author

C-reactive protein as a predicting factor for difficult laparoscopic cholecystectomy or its conversion to open cholecystectomy in acute calculous cholecystitis: an observational study.

BMC surgery·2026

Related Experiment Video

Updated: Sep 15, 2025

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
06:07

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

2.5K

HIV Cure: How Far We Have Come?

Shesh Prakash Maurya1, Abhishek Shrivastav1, Vivek Singh Rawat1

  • 1National HIV/AIDS Reference Laboratory, All India Institute of Medical Sciences, New Delhi, Delhi India.

Indian Journal of Microbiology
|July 14, 2025
PubMed
Summary

A functional cure for Human Immunodeficiency Virus (HIV) is crucial. This review explores latent HIV reservoirs and innovative strategies like stem cell transplants and gene therapy for HIV remission or eradication.

Keywords:
AIDSHIVHIV cureHIV cure strategiesHIV remissionLatent reservoir

More Related Videos

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
05:46

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

18.0K
High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing
07:18

High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing

Published on: January 22, 2019

5.9K

Related Experiment Videos

Last Updated: Sep 15, 2025

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
06:07

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

2.5K
Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
05:46

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

18.0K
High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing
07:18

High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing

Published on: January 22, 2019

5.9K

Area of Science:

  • Virology
  • Immunology
  • Infectious Diseases

Background:

  • Human Immunodeficiency Virus (HIV) presents a significant global health challenge, with current treatments managing but not curing the infection.
  • Antiretroviral therapy (ART) extends life expectancy, but an estimated 42 million people will live with HIV by 2030.
  • A cure, defined as remission or eradication of the virus, is urgently needed.

Purpose of the Study:

  • To review recent advancements in understanding latent HIV reservoirs.
  • To discuss natural models of functional HIV cure.
  • To explore emerging therapeutic strategies for achieving a functional HIV cure.

Main Methods:

  • Review of basic, applied, and clinical research on latent HIV reservoirs.
  • Analysis of tissue locations, cell types, properties, and integration sites of HIV reservoirs.
  • Examination of reservoir seeding mechanisms and study methodologies.
  • Discussion of natural controllers and novel therapeutic approaches.

Main Results:

  • Latent HIV reservoirs are established in various tissues and cell types, posing a significant barrier to cure.
  • Natural models like elite controllers offer insights into spontaneous viral control.
  • Emerging strategies show promise for targeting latent reservoirs and achieving durable viral control.

Conclusions:

  • Understanding and targeting latent HIV reservoirs is key to developing a functional cure.
  • Innovative approaches including stem cell transplantation, gene therapy, and 'shock and kill' or 'block and lock' strategies are being investigated.
  • Combined strategies may offer the most effective path towards HIV remission or eradication.