Jove
Visualize
Contact Us

Related Concept Videos

Biological Methods for Microbial Control01:28

Biological Methods for Microbial Control

209
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
209
Gram-negative Bacterial Protein Secretion Systems01:17

Gram-negative Bacterial Protein Secretion Systems

160
Gram-negative bacteria utilize sophisticated protein secretion systems to transport proteins across their double-membrane envelope into the extracellular environment or host cells. Based on their mechanism of action, these systems are classified into one-step and two-step pathways.One-Step Secretion Systems (Types I, III, IV, and VI)One-step secretion systems bypass the periplasm entirely, forming a continuous channel that spans both the inner and outer membranes:Type I Secretion System (T1SS):...
160
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

96
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
96
Transduction01:16

Transduction

120
Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome...
120

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Age-independent immune subtypes in type 1 diabetes exhibit distinct post-onset progression rates and immunotherapeutic responses.

Diabetologia·2026
Same author

Nutrients and bioactive compounds as modifiers of neurodegenerative trajectories: molecular mechanisms, translational barriers, and precision nutrition.

Frontiers in nutrition·2026
Same author

Efficient molecular solar thermal energy storage in self-assembled columnar triethynylbenzene-azobenzene systems.

Chemical communications (Cambridge, England)·2026
Same author

Human iPSC-derived and conventional cancer models in precision oncology: advancing patient-specific therapies from bench to bedside.

Journal of experimental & clinical cancer research : CR·2026
Same author

Decoding the RNA Shield: HNRNPC and YTHDF2 Act as Guardians of Neurons in Parkinson's Disease.

Neurotoxicity research·2026
Same author

Role of LncRNA NEAT1 in Alzheimer's Disease: Pathophysiological Insights and Therapeutic Approaches.

Neurotoxicity research·2026
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Sep 15, 2025

Measuring Growth and Gene Expression Dynamics of Tumor-Targeted S. Typhimurium Bacteria
08:11

Measuring Growth and Gene Expression Dynamics of Tumor-Targeted S. Typhimurium Bacteria

Published on: July 6, 2013

13.0K

Targeting Type III Secretion System using Salmonella: A Promising Candidate for Innovative Antibacterial Therapy.

Shreya1, Tarun Pant1, Swadha Kailoo1

  • 1Department of Biological Sciences and Engineering (BSE), Netaji Subhas University of Technology (NSUT), New Delhi, 110078 India.

Indian Journal of Microbiology
|July 14, 2025
PubMed
Summary

Combating drug-resistant bacteria requires new strategies. Targeting the Type III secretion system (T3SS) with inhibitors offers a promising antivirulence approach to disarm pathogens and develop novel antibacterial therapies.

Keywords:
InhibitorsSalmonellaType III secretion systemTyphoidVirulence

More Related Videos

Super-Resolution Imaging of Bacterial Secreted Proteins Using Genetic Code Expansion
13:11

Super-Resolution Imaging of Bacterial Secreted Proteins Using Genetic Code Expansion

Published on: February 10, 2023

1.6K
Quantifying Yersinia pseudotuberculosis Type III Secretion System Activity Following Iron Starvation and Anaerobic Growth
08:36

Quantifying Yersinia pseudotuberculosis Type III Secretion System Activity Following Iron Starvation and Anaerobic Growth

Published on: May 31, 2024

554

Related Experiment Videos

Last Updated: Sep 15, 2025

Measuring Growth and Gene Expression Dynamics of Tumor-Targeted S. Typhimurium Bacteria
08:11

Measuring Growth and Gene Expression Dynamics of Tumor-Targeted S. Typhimurium Bacteria

Published on: July 6, 2013

13.0K
Super-Resolution Imaging of Bacterial Secreted Proteins Using Genetic Code Expansion
13:11

Super-Resolution Imaging of Bacterial Secreted Proteins Using Genetic Code Expansion

Published on: February 10, 2023

1.6K
Quantifying Yersinia pseudotuberculosis Type III Secretion System Activity Following Iron Starvation and Anaerobic Growth
08:36

Quantifying Yersinia pseudotuberculosis Type III Secretion System Activity Following Iron Starvation and Anaerobic Growth

Published on: May 31, 2024

554

Area of Science:

  • Microbiology
  • Bacterial Pathogenesis
  • Drug Discovery

Background:

  • Multiple drug-resistant (MDR) bacterial strains present a significant global health challenge.
  • Developing new antibiotics is difficult, necessitating novel therapeutic targets and strategies.
  • The antivirulence approach targets bacterial virulence factors rather than viability.

Purpose of the Study:

  • To review the Type III secretion system (T3SS) as a target for novel antibacterial therapies.
  • To discuss the assembly, visualization, and inhibition of T3SS.
  • To explore the potential of T3SS inhibitors in combating MDR bacteria.

Main Methods:

  • Literature review of T3SS structure, function, and inhibition strategies.
  • Analysis of small molecules, peptides, and antibodies targeting T3SS.
  • Examination of T3SS function in model organisms like *Salmonella*.

Main Results:

  • T3SS is a critical virulence factor in many Gram-negative bacteria, acting as an injection system for effector proteins.
  • Various small molecules, peptides, and antibodies are being developed to inhibit T3SS assembly and function.
  • Preclinical evaluations in animal models show promise for T3SS inhibitors as antivirulence agents.

Conclusions:

  • Inhibiting T3SS represents a viable antivirulence strategy against MDR bacteria.
  • T3SS inhibitors could revolutionize antibacterial therapy by offering a new mode of action.
  • Further research into T3SS mechanisms and inhibitors is crucial for developing next-generation treatments.