Hypocalcemia is associated with adverse outcomes in patients with diabetes and COVID-19
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View abstract on PubMed
Summary
This summary is machine-generated.Hypocalcemia, or low serum calcium levels, is common in diabetic patients with COVID-19. This condition significantly increases the risk of severe illness and poor prognosis in these individuals.
Area Of Science
- Endocrinology
- Infectious Diseases
- Critical Care Medicine
Background
- Patients with diabetes mellitus (DM) and coronavirus disease 2019 (COVID-19) exhibit a poorer prognosis.
- Investigating the prevalence of hypocalcemia and its impact on prognosis in this patient cohort is crucial.
Purpose Of The Study
- To determine the prevalence of hypocalcemia in diabetic patients diagnosed with COVID-19.
- To assess the association between serum calcium levels and the clinical outcomes of COVID-19 in diabetic patients.
Main Methods
- A retrospective analysis included 919 diabetic patients admitted with COVID-19 between February 2022 and May 2022.
- Patients were stratified into groups based on serum calcium levels.
- Logistic regression analysis evaluated the link between hypocalcemia and COVID-19 prognosis, including severe illness and need for advanced respiratory support.
Main Results
- The prevalence of hypocalcemia was 78.8% among the studied diabetic COVID-19 patients.
- Lower serum calcium levels correlated with elevated inflammatory markers and reduced CD4+/CD8+ T cell counts.
- Hypocalcemia (serum calcium <1.94 mmol/L) was independently associated with an increased risk of severe COVID-19 (OR 2.86, P<0.001).
Conclusions
- Admission serum calcium levels are a significant prognostic indicator in diabetic patients with COVID-19.
- Hypocalcemia is linked to an increased risk of disease progression and severity in this population.
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