Enhanced Cleaning, Enhanced Healing: A Systematic Review of Advances in Endodontic Irrigation

Effective irrigation is crucial for successful endodontic treatment, ensuring debris removal, disinfection, and biofilm elimination. This systematic review analyzes recent advances in endodontic irrigants and activation systems.

A comprehensive search of PubMed, Scopus, Web of Science, and Google Scholar was conducted to identify relevant studies published between 2015 and 2025.

Emerging irrigants, including nanoparticle-based solutions, herbal formulations, and photoactivated disinfectants, demonstrate promising antimicrobial and biocompatibility properties. Advanced irrigation activation techniques, such as ultrasonic, laser-activated, and multisonic irrigation, enhance root canal debridement efficacy.

This review highlights the strengths and limitations of recent advancements in endodontic irrigation, providing insights into their clinical implications and future research directions.