Assessment of Platelet-Rich Fibrin (PRF) in Enhancing Periodontal Regeneration

Restoring the structure and functionality of periodontal tissues is the goal of the intricate biological process known as periodontal regeneration. Autologous blood products like platelet-rich fibrin (PRF) have drawn interest because of their capacity to hasten healing and encourage tissue regeneration.

This randomized clinical study included 30 patients with chronic periodontitis who needed regenerative periodontal treatment. Patients were split into two groups: 15 patients in the test group got PRF together with bone transplant, while 15 patients in the control group received bone graft alone. At baseline, 3 months, and 6 months after surgery, clinical measures such as radiographic bone fill, clinical attachment level (CAL), and probing depth (PD) were measured. Analysis of variance and paired t-tests were used for statistical analysis of the data.

When compared to the control group, the test group's clinical results after 6 months were noticeably better. The test group's mean PD decrease was 4.2 ± 0.8 mm, whereas the control group's was 3.0 ± 0.6 mm (P < 0.05). The test group's CAL increase was 3.5 ± 0.7 mm, whereas the control group's was 2.6 ± 0.5 mm (P < 0.05). According to the radiographic study, the test group had a higher percentage of bone fill (68%) than the control group (45%).

When compared to standard therapy alone, the inclusion of PRF dramatically improved periodontal regeneration in terms of CAL gain, bone fill, and PD reduction. PRF deserves further research in bigger clinical trials since it is a potential adjuvant in regenerative periodontal treatment.