Related Experiment Video
Updated: Sep 15, 2025

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
Published on: March 14, 2025
Predicting OCD severity from religiosity and personality: A machine learning and neural network approach
Brian A Zaboski1, Alixandra Wilens1, Joseph P H McNamara2
1Department of Psychiatry, Yale University, New Haven, CT, USA.
Abstract:
Obsessive-compulsive disorder (OCD) affects a significant portion of the United States population. The present study investigated the complex relationships among OCD severity, personality traits, religiosity, and spirituality with a dataset of 229 participants. We applied advanced machine and deep learning techniques to identify key predictors of OCD severity, uncovering nuanced relationships and unexpected findings. Notably, item-level features were more influential than aggregate scores, challenging traditional analytical approaches. Moreover, a neural network model, despite not surpassing a linear regression in predictive accuracy, provided a more comprehensive understanding of OCD's heterogeneity and of the nonlinear relationships between our variables. The inclusion of demographic factors provided further explanatory power for predicting OCD severity, emphasizing the multifaceted nature of the disorder. Our results show that machine learning models can nearly match traditional linear models in predictive power while retaining nonlinear relationships essential to understanding OCD. Our study advocates for the adoption of sophisticated predictive models in examining complex psychological phenomena, encouraging a reevaluation of conventional analytical approaches when prediction is central to research questions.
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