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Interplay between MAPK signaling pathway and autophagy in skin aging: mechanistic insights and therapeutic

Xu Liu1, Bo Chen2, Xuefeng Liu3

  • 1The First Clinical College, Liaoning University of Traditional Chinese Medicine, Shenyang, China.

Frontiers in Cell and Developmental Biology
|July 14, 2025
PubMed

Insights

Skin aging involves the mitogen-activated protein kinase (MAPK) pathway and autophagy. Understanding their interplay in skin cells can lead to new anti-aging strategies using natural compounds.

Area of Science:

  • Dermatology and cellular biology.
  • Investigating molecular mechanisms of skin aging.

Background:

  • Skin aging involves structural and functional decline, linked to oxidative stress and the MAPK pathway.
  • Autophagy plays a dual role in skin aging, offering protection but also dysfunction.

Purpose of the Study:

  • To review the interplay between MAPK signaling and autophagy in skin aging.
  • To explore cell-type-specific regulatory networks in keratinocytes, fibroblasts, and melanocytes.
  • To assess the therapeutic potential of natural compounds targeting this interplay.

Main Methods:

  • Literature review synthesizing current evidence on MAPK-autophagy interactions.
  • Analysis of cell-type-specific regulatory mechanisms in cutaneous aging.
  • Exploration of natural bioactive compounds for therapeutic intervention.

Main Results:

  • The MAPK-autophagy axis critically influences skin aging progression.
  • Cell-type-specific regulatory networks govern aging in keratinocytes, fibroblasts, and melanocytes.
  • Targeting this interplay shows therapeutic promise for combating skin aging.

Conclusions:

  • The MAPK-autophagy interplay is a key modulator of skin aging.
  • Understanding these cell-specific interactions is crucial for developing effective anti-aging therapies.
  • Natural compounds offer a promising avenue for clinical translation in skin aging treatment.
Keywords:
MAPKautophagyinterplaynatural bioactive compoundsskin aging

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