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Published on: August 11, 2015
Fixed dose combination dextromethorphan-bupropion: A hope for treatment resistant depression (TRD)
Ranjan Das1, Rajarshi Chakravarty2, Varaha V Gantait3
1Department of Psychiatry, IOP-COE, IPGMER, Kolkata, West Bengal, India.
Background:
Treatment resistant depression (TRD) has been identified as non-response to depression with adequate dose and trial of two antidepressant medications of different classes. Near about 30% depressive patients are TRD cases. Olanzapine-fluoxetine combination, rTMS, Intravenous ketamine and Electroconvulsive therapy have been till now studied in TRD. Dextromethorphan-bupropion is a newer antidepressant, which has been found to be effective, fast-acting, and well tolerated medicine for depression.
Cases And Conclusion:
We used this novel antidepressant in three cases of TRD, alone and with combination, and it showed satisfactory response within 2 weeks.
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