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Updated: Sep 15, 2025

Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses
Published on: September 28, 2018
Exploring adjunctive continuous theta burst stimulation for treatment-resistant auditory hallucinations in
Sukriti Mukherjee1, Jayashree Kalita1, Trishita Chatterjee1
1Department of Psychiatry, All India Institute of Medical Sciences, Kalyani, West Bengal, India.
Background:
Auditory hallucinations affect 60%-80% of schizophrenia patients, often causing distress and functional impairment. Despite antipsychotic treatment, 30% remain resistant. Dysfunctional prefrontal-temporal connectivity has been found to be associated with these symptoms. Repetitive Transcranial Magnetic Stimulation (rTMS) is a neuromodulation technique that targets the dysfunctional area and is being used for treatment of persistent auditory hallucinations in Schizophrenia with mixed results. Continuous Theta Burst Stimulation (cTBS) is a novel neuromodulation technique that works on the principals of rTMS with similar or more robust clinical efficacy.
Cases:
We describe the cases of three patients where cTBS was applied.
Conclusion:
Significant improvement in auditory hallucinations was noticed in all three patients. While this evidence must be interpreted with caution, future studies on this topic with robust protocol to be conducted.
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