Related Experiment Video
Updated: Sep 15, 2025

Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3
Published on: April 7, 2023
The Role of JAK Inhibitors in Pediatric Lichen Sclerosus et Atrophicus: A Case Report
Shivangi Sharma1, Akanksha Bandhade1, Mrityunjay K Singh1
1Dermatology, Pandit Jawaharlal Nehru Memorial Medical College and Dr. Bhimrao Ambedkar Memorial Hospital, Raipur, IND.
Abstract:
Lichen sclerosus (LS) is an uncommon mucocutaneous condition that primarily affects the genitoanal region and is characterized by white, porcelain-like sclerotic lesions. Although its incidence peaks after menopause, LS can also occur in children, affecting both the genital and extragenital areas. We present the case of a pediatric patient with both genital and extragenital LS who responded well to oral tofacitinib therapy. This case highlights that oral tofacitinib is a safe and effective treatment option for lichen sclerosus et atrophicus (LSA) in the pediatric population.
Related Concept Videos
The JAK-STAT Signaling Pathway
Antiasthma Drugs: Leukotriene Modifiers
Leukotriene modifiers work through two distinct mechanisms:
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Immunodeficiency Diseases
There are three main causes of immunodeficiency...
Inhibition of Cdk Activity

