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Updated: Sep 15, 2025

A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties
Published on: August 7, 2020
Exploring the impact of galectins on liver cancer: From immunopathogenesis to potential targets
Nevena M Gajovic1, Ivan P Jovanovic1, Miodrag V Jocic2
1Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Kragujevac 34000, Serbia.
Abstract:
Liver cancer remains one of the leading causes of cancer-related mortality worldwide, with hepatocellular carcinoma representing its most prevalent form. This review provides a comprehensive summary of the key factors driving the initiation and progression of hepatocellular carcinoma, with a particular emphasis on immune-related mechanisms. Furthermore, we delve into the emerging roles of galectins, particularly galectin-1 and galectin-3, in hepatocellular carcinoma pathobiology, underscoring their potential utility as biomarkers for assessing disease severity and progression. These insights contribute to a better understanding of the molecular and immunological underpinnings of hepatocellular carcinoma, paving the way for more targeted therapeutic strategies.
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