Training Africans to Lead and Execute Neurological Trials and Studies (TALENTS): program overview and rationale

Area of Science:

• Global Health
• Neuroscience Research Capacity Building
• Clinical Trials in Africa

Background:

• Africa faces a high burden of neurological diseases but lacks representation in clinical research.
• This disparity hinders precision medicine development for African populations.
• Existing research infrastructure and training opportunities are insufficient.

Purpose of the Study:

• To establish sustainable neurological research capacity in Africa through the TALENTS program.
• To train African scholars in clinical neuroscience research, trial design, and grant writing.
• To foster academic career development and mentorship within African neuroscience.

Main Methods:

• The TALENTS program, a Fogarty International Research Training D-43 initiative, partners U.S. institutions with the University of Ibadan and the African Academy of Neurology (AFAN).
• Recruited and trained 20 multidisciplinary African scholars (post-doctoral researchers and clinicians) in clinical neuroscience.
• Scholars completed a Certificate in Clinical Research, with some pursuing Master's degrees, and engaged in mentorship and networking activities.

Main Results:

• As of February 2025, 15 scholars across three cohorts have advanced in their careers.
• Notable progress includes faculty appointments and the commencement of PhD studies.
• The program is successfully producing a cadre of independent investigators.

Conclusions:

• The TALENTS program effectively builds neurological research capacity in Africa.
• It addresses global health disparities by enhancing local expertise and infrastructure.
• The initiative has broader implications for improving neurological health outcomes in African and African American populations.