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Novel risk prediction model for major adverse cardiovascular events in minimally invasive mitral valve surgery: a

Hongye Bai1,2, Jingwei Zhang2, Yi Xu2

  • 1Department of Thoracic and Cardiovascular Surgery, Capital Medical University, Beijing, China.

Cardiovascular Diagnosis and Therapy
|July 14, 2025
PubMed
Abstract

Insights

Minimally invasive mitral valve surgery (MIMVS) requires a new risk model. The CompliMit Score accurately predicts major adverse cardiovascular events (MACE) in MIMVS patients, outperforming existing tools.

Area of Science:

  • Cardiovascular Surgery
  • Thoracic Surgery
  • Medical Technology

Background:

  • Minimally invasive mitral valve surgery (MIMVS) is standard for mitral valve pathologies.
  • Current cardiac risk models inadequately assess MIMVS-specific perfusion and ventilation techniques.
  • This leads to imprecise prediction of perioperative risks.

Purpose of the Study:

  • Identify perioperative risk factors for major adverse cardiovascular events (MACE) in MIMVS.
  • Develop and validate a novel predictive model for MACE in MIMVS patients.

Main Methods:

  • Retrospective study of 480 MIMVS patients.
  • Collected data on 79 perioperative clinical variables.
  • Developed the CompliMit Score using elastic net regression and validated with bootstrap replicates.

Main Results:

  • The 30-day MACE rate was 12%.
  • 31 clinical variables (pre-, intra-, and postoperative) correlated with MACE.
  • The CompliMit Score (14 risk factors) demonstrated superior MACE prediction (AUC 0.92) compared to EuroSCORE II (AUC 0.67).

Conclusions:

  • Preoperative, intraoperative, and postoperative factors influence MIMVS prognosis.
  • The CompliMit Score effectively identifies high-risk patients for perioperative MACE.
  • This facilitates targeted postoperative care and optimized resource allocation.
Keywords:
Minimally invasive mitral valve surgery (MIMVS)major adverse cardiovascular events (MACEs)mitral valve surgeryrisk prediction model

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