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Clinical Efficacy of Mind-Regulating Acupuncture on Post-Stroke Depression Based on the "Microbiota-Gut-Brain Axis"
Jingjun Xie1, Jinxia Li2, Qi Sun1
1Department of Acupuncture, The First People's Hospital of Huzhou, Huzhou, Zhejiang Province, People's Republic of China.
Objective:
This study explored the clinical efficacy and mechanisms of Mind-Regulating Acupuncture (MRA) for post-stroke depression (PSD) based on the "microbiota-gut-brain axis" theory.
Methods:
92 PSD patients were randomly divided into an observation group (received conventional therapy + MRA) and a control group (conventional therapy only). After 8 weeks of treatment, multiple indicators including depression scores, neurological function scores, and levels of neurotransmitters and gut microbiota were compared.
Results:
MRA significantly improved depressive symptoms, neurological function, and daily living abilities in PSD patients. It increased serum 5-HT and BDNF levels, and regulated gut microbiota, promoting beneficial bacteria and reducing harmful ones.
Conclusion:
MRA effectively treats PSD, and its mechanism may involve regulating the "microbiota-gut-brain axis", increasing beneficial gut bacteria, and enhancing 5-HT and BDNF levels.
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