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NDL-Net: A Hybrid Deep Learning Framework for Diagnosing Neonatal Respiratory Distress Syndrome From Chest X-Rays
Malik Muhammad Arslan1, Xiaodong Yang1, Nan Zhao1
1Key Laboratory of High Speed Circuit Design and EMC of Ministry of Education, School of Electronic EngineeringXidian University Xi'an 710071 China.
IEEE Open Journal of Engineering in Medicine and Biology
|July 14, 2025
Summary
A new deep learning model, NDL-Net, accurately diagnoses Neonatal Respiratory Distress Syndrome (NRDS) using chest X-rays. This AI tool improves early detection and management of NRDS in newborns.
Area of Science:
- Medical Imaging
- Artificial Intelligence
- Neonatal Medicine
Background:
- Neonatal Respiratory Distress Syndrome (NRDS) is a critical condition in newborns.
- Accurate and timely diagnosis of NRDS is essential for effective treatment.
- Current diagnostic methods may have limitations in speed and accuracy.
Purpose of the Study:
- To introduce NDL-Net, a novel hybrid deep learning framework for NRDS diagnosis.
- To evaluate the diagnostic performance of NDL-Net using neonatal chest X-rays (CXR).
- To improve the early detection and management of NRDS in neonates.
Main Methods:
- Developed NDL-Net, a hybrid deep learning architecture.
- Integrated MobileNetV3 Large for image processing and ResNet50 for pattern detection.
- Incorporated a Long Short-Term Memory (LSTM) layer for temporal data analysis.
Main Results:
- NDL-Net achieved high diagnostic performance on neonatal CXR datasets.
- Achieved 98.09% accuracy, 97.45% precision, 98.73% sensitivity, 98.08% F1-score, and 98.73% specificity.
- Demonstrated low false negative and false positive rates, indicating superior diagnostic capability.
Conclusions:
- NDL-Net signifies a substantial advancement in medical diagnostics for NRDS.
- The framework enhances neonatal care through improved early detection of NRDS.
- NDL-Net offers a promising tool for the timely management of NRDS in newborns.
Keywords:
AI-driven diagnosischest X-ray imagingcomputational pediatric radiologyhybrid deep learning frameworkneonatal respiratory distress syndrome
