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Nanodroplets versus Nanofibers Ion-Selective Optodes toward Biocompatible Sensors
Anna Konefał1,2, Justyna Kalisz1, Emilia Stelmach1
1Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.
ACS Omega
|July 14, 2025
Summary
This study compares ion-selective optodes in nanodroplet and nanofiber formats using optical transducers. Nanofiber optodes offer advantages for sensing in various solutions and reusable applications.
Area of Science:
- Analytical Chemistry
- Materials Science
- Biomedical Engineering
Background:
- Ion-selective optodes are crucial for chemical sensing.
- Nanostructural formats offer potential improvements in sensor performance.
- Developing sensors for unbuffered samples remains a challenge.
Purpose of the Study:
- To compare the performance of ion-selective optodes in nanodroplet and nanofiber formats.
- To investigate the use of Nile blue/Nile red-based systems as optical transducers.
- To evaluate calcium sensors in different nanostructural formats.
Main Methods:
- Preparation of ion-selective optodes in nanodroplet and polycaprolactone nanofiber formats.
- Utilizing Nile blue and Nile red as optical transducers.
- Testing calcium sensors in unbuffered aqueous samples.
Main Results:
- Both nanodroplet and nanofiber optodes showed increased Nile red emission with higher calcium concentrations.
- Nile blue emission changes were format-dependent.
- A linear relationship was observed between emission intensity ratio and calcium concentration (10⁻⁵ to 10⁻¹ M).
Conclusions:
- Nanofiber optodes provide advantages for sensing in solution and reusability.
- The developed optodes are suitable for unbuffered samples.
- Nanofiber mats offer a promising platform for advanced optical sensing applications.
