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Updated: Sep 15, 2025
A Rapid and Efficient Method to Dissect Pupal Wings of Drosophila Suitable for Immunodetections or PCR Assays
Published on: December 30, 2017
Role of AdamTS-B in Drosophila wing vein formation
Jana Schulze1,2, Uwe Töpfer3,2
1Section of Molecular Hematology, Department of Hematology/Oncology University Hospital Freiburg, University of Freiburg, Freiburg im Breisgau, Baden-Wurttemberg, Germany.
Abstract:
The development of Drosophila wing veins is a complex morphogenetic process that depends on the interplay of different signaling pathways, including EGFR, BMP, Notch, Hedgehog and Wnt. Basement membranes (BMs) and proteases that process BM components play a crucial role in controlling the morphogen spreading and associated patterning required for proper organ formation. Here we show, that AdamTS-B is required for the proper development of Drosophila wing veins. Knockdown of AdamTS-B results in various phenotypes, including additional veins, delta branches, and wandering veins within different longitudinal veins, though there are no differences in the cross veins.
