Related Experiment Video

Updated: Sep 15, 2025

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.5K

Long-term Cardiovascular Outcomes in Patients with Omicron COVID-19 and Elevated Cardiac Biomarkers: A Prospective

Shun Yao1, Yamei Xu1, Zhonglei Xie1,2

  • 1Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, China.

International Journal of Medical Sciences
|July 14, 2025
PubMed

Insights

Elevated cardiac biomarkers, including cardiac troponin T (cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP), in hospitalized SARS-CoV-2 omicron patients indicate a higher risk for major adverse cardiovascular events and death within 12 months.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Long-term cardiovascular outcomes following SARS-CoV-2 omicron infection are not well-established.
  • Hospitalized patients with elevated cardiac biomarkers require further risk assessment.

Purpose of the Study:

  • To evaluate acute and long-term cardiovascular risks in hospitalized SARS-CoV-2 omicron-infected patients.
  • To assess the predictive value of cardiac biomarkers for adverse cardiovascular events.

Main Methods:

  • A cohort of 3012 hospitalized patients in Shanghai, China, were analyzed.
  • Patients were stratified based on cardiac troponin T (cTnT) and NT-proBNP levels.
  • Major adverse cardiovascular events (MACEs), mortality, and rehospitalization were tracked over 12 months.

Main Results:

  • Elevated cTnT and NT-proBNP significantly increased the risk of MACEs, all-cause death, cardiovascular death, and cardiovascular-related rehospitalization.
  • These risks were independent of common comorbidities like hypertension and heart failure.
  • Hazard ratios for MACEs and death were substantially elevated in patients with dual biomarker elevation.

Conclusions:

  • Elevated cTnT and NT-proBNP during acute omicron infection are significant predictors of adverse cardiovascular outcomes.
  • Biomarker levels in the acute phase can identify high-risk patients needing closer cardiovascular monitoring.
  • This highlights the importance of cardiac biomarker assessment in managing omicron patients.

Keywords:
N-terminal pro-B-type natriuretic peptide (NT-proBNP)Omicron variantcardiac troponins T (cTnT)coronavirus disease 2019 (COVID-19)severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

More Related Videos

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model07:35

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model

Published on: December 10, 2021

2.1K
Effects of Surgical Masks on Cardiopulmonary Function in Healthy Subjects06:57

Effects of Surgical Masks on Cardiopulmonary Function in Healthy Subjects

Published on: February 12, 2021

3.3K

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
342
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
218
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
25
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
54
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
37
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
38