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Causal Relationship between Gut Microbiota and Endometrial Cancer: A Two-Sample Mendelian Randomization Study
Xinrui Yao1,2, Sitong Dong1,2,3,4, Xiao Li1,2
1Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang, 110004, China.
International Journal of Medical Sciences
|July 14, 2025
Summary
Gut bacteria composition influences endometrial cancer (EC) risk. Specific bacteria like Ruminococcus gnavus group and Euryarchaeota show protective effects, while Gammaproteobacteria increase EC risk.
Area of Science:
- Microbiome research
- Oncology
- Genetics
Background:
- Gut microbiota alterations are linked to endometrial cancer (EC) pathogenesis.
- The causal role of gut microbiota in EC development remains unclear.
Purpose of the Study:
- To investigate the causal relationship between gut microbiota composition and endometrial cancer (EC).
- To assess the impact of specific gut bacteria on EC, including endometrioid and non-endometrioid subtypes.
Main Methods:
- A two-sample Mendelian randomization (MR) study utilizing genetic data from 18,340 participants.
- Instrumental variables (SNPs) were selected based on genome-wide association study (GWAS) data for gut microbiota and EC.
- Causal effects were analyzed using multiple MR methods including Inverse-Variance Weighted (IVW).
Main Results:
- Ruminococcus gnavus group, Euryarchaeota, and Candidatus Soleaferrea exhibited protective effects against EC.
- Gammaproteobacteria were identified as a risk factor for EC.
- Intestinimonas showed detrimental effects on EC with non-endometrioid histologies.
Conclusions:
- This study provides evidence for a causal link between specific gut bacteria and endometrial cancer.
- Findings contribute to understanding the gut microbiota's role in EC development.
- Identified bacteria may represent potential targets for EC prevention or treatment.
