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Healthcare resource utilisation and costs associated with hypertension in children and adolescents: a
Junayd Hussain1, Rabeeyah Ahmed1, Cal H Robinson2,3
1Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
Insights
Paediatric hypertension significantly increases healthcare use and costs in children. Early intervention is crucial to mitigate long-term health and economic burdens associated with childhood high blood pressure.
Area of Science:
- Public Health
- Cardiology
- Health Economics
Background:
- Global rise in paediatric hypertension poses risks for cardiovascular and kidney health.
- Uncertainty exists regarding healthcare resource utilization and costs linked to childhood hypertension.
- This study quantifies healthcare utilization and associated costs in hypertensive children.
Purpose of the Study:
- To evaluate healthcare resource utilization among children diagnosed with hypertension.
- To determine the healthcare costs associated with paediatric hypertension.
- To compare healthcare utilization and costs between hypertensive children and their peers.
Main Methods:
- Population-based retrospective cohort study in Ontario, Canada (1993-2021).
- Propensity score matching compared 25,605 hypertensive children with 128,025 controls.
- Negative binomial regression assessed healthcare utilization; secondary outcomes included costs and specialist follow-up.
Main Results:
- Hypertensive children experienced higher rates of hospitalizations (RR 2.13), emergency visits (RR 1.08), and outpatient visits (RR 1.33).
- Mean healthcare costs were substantially higher for hypertensive children, particularly in the first year ($16,690 vs $2659 per person-year).
- Comorbidities like congenital heart disease, malignancy, diabetes, and chronic kidney disease were uncommon.
Conclusions:
- Youth with hypertension demonstrate significantly increased healthcare resource utilization.
- Findings support the need for cost-effectiveness analyses of paediatric hypertension prevention strategies.
- Understanding the economic impact is vital for managing childhood hypertension and its sequelae.
Background:
The global prevalence of paediatric hypertension has increased, contributing to long-term cardiovascular and kidney morbidity. However, healthcare resource utilisation and costs attributable to paediatric hypertension remain uncertain. This study evaluates healthcare utilisation and costs among hypertensive children compared to controls.
Methods:
In a population-based retrospective cohort study, we analysed youth (aged 3-18 years) diagnosed with hypertension in Ontario, Canada (1993-2021). Using propensity score matching, 25,605 hypertensive children were compared to 128,025 controls and followed until death, emigration, or 31 March 2022. Healthcare utilisation (hospitalisations, emergency visits, outpatient visits) was assessed via negative binomial regression. Secondary outcomes included healthcare costs and specialist follow-up.
Findings:
Median age was 15 years [IQR 11-17], 49% were female, and comorbidities were uncommon (4% (6497/153,630) congenital heart disease, 2% (9359/153,630) malignancy, 2% (2892/153,630) diabetes, 1% (2004/153,630) chronic kidney disease). Over a median follow-up of 12.9 [IQR 6.8-19.9] years, hypertensive children had higher hospitalisations (rate ratio [RR] 2.13, 95% CI 2.03-2.22), emergency visits (RR 1.08, 95% CI 1.05-1.11), and outpatient visits (RR 1.33, 95% CI 1.31-1.34). Mean healthcare costs were substantially higher in children with hypertension, especially in the first year ($16,690 vs $2659 per person-year).
Interpretation:
Healthcare resource utilisation was significantly higher in youth with hypertension. These findings provide a basis for future cost-effectiveness studies on preventing paediatric hypertension and its complications.
Funding:
This study was funded in part by a 2021/2022 CoRE Builder Team Grant from McMaster University's Department of Paediatrics and supported by ICES Western, funded by the Ontario Ministry of Health (MOH) and Ministry of Long-Term Care.
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