Related Experiment Video

Updated: Sep 15, 2025

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

86.4K

Risk factors of mild behavioral impairment: a systematic review

Song Lin Tang1,2, Ponnusamy Subramaniam2, Ching Sin Siau3

  • 1Department of Geriatrics, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, China.

Frontiers in Psychology
|July 14, 2025
PubMed
Abstract

Insights

Mild Behavioral Impairment (MBI) is a predementia syndrome. Key factors include genetics, motor and sensory deficits, metabolic issues, and brain changes, highlighting the need for early detection in neurodegenerative disorders.

Area of Science:

  • Neuroscience
  • Gerontology
  • Psychiatry

Background:

  • Mild Behavioral Impairment (MBI) is a syndrome of neuropsychiatric symptoms preceding cognitive decline.
  • Identifying MBI-associated factors is crucial for neurodegenerative disorder prevention.

Purpose of the Study:

  • To systematically review factors associated with Mild Behavioral Impairment (MBI).
  • To synthesize evidence for MBI pathogenesis and inform prevention strategies.

Main Methods:

  • Systematic review following PRISMA 2020 guidelines.
  • Searched major databases (PubMed, Scopus, Web of Science, etc.) through May 2024.
  • Included 41 human studies selected via dual independent screening.

Main Results:

  • Five key domains associated with MBI identified: genetic susceptibility (APOE ε4), motor pathology (Parkinsonism), multisensory deficits (auditory), metabolic dysregulation (diabetes, frailty), and neuroanatomical correlates (frontolimbic atrophy).
  • Interaction between genetic and environmental/lifestyle factors is central to MBI development.

Conclusions:

  • MBI is a complex interface between molecular mechanisms and clinical presentation.
  • Supports transdiagnostic screening integrating behavioral biomarkers and cognitive assessments.
  • Recommends longitudinal studies to establish causal pathways and intervention thresholds.
Keywords:
Alzheimer’s diseasecognitive declinemild behavioral impairmentrisk factorssystematic review

More Related Videos

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.6K
Strategies for Assessing Autistic-Like Behaviors in Mice07:38

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

1.3K

Related Concept Videos

Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
295
Behavior Modification01:21

Behavior Modification

Behavioral approaches have often been criticized for ignoring mental processes and focusing solely on observable behavior. However, these approaches provide an optimistic perspective for individuals seeking to change their behaviors. Rather than concentrating on intrinsic personality traits, behavioral approaches suggest that even longstanding habits can be modified by changing the reward contingencies that maintain them.
A real-world application of operant conditioning principles is applied...
236
Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
340
Conduct Disorder01:28

Conduct Disorder

Conduct disorder is a complex mental health diagnosis characterized by a repetitive and persistent pattern of behavior that violates societal norms, the rights of others, or age-appropriate rules. The diagnostic criteria for conduct disorder require the presence of at least three problematic behaviors within the past 12 months, with at least one occurring in the past six months. These behaviors are grouped into four categories: aggression toward people and animals; destruction of property;...
108
Operant Conditioning Intervention01:24

Operant Conditioning Intervention

Operant conditioning serves as a foundational principle in therapeutic interventions aimed at modifying maladaptive behaviors. Central to this approach is the notion that behaviors, both adaptive and maladaptive, are learned through reinforcement. By analyzing the environmental factors that reinforce problematic behaviors, clinicians can design interventions to weaken these reinforcements and replace maladaptive behaviors with healthier alternatives.
In operant conditioning, behaviors that are...
119
Oppositional Defiant Disorder01:30

Oppositional Defiant Disorder

A persistent pattern of angry or irritable mood, defiant behavior, or vindictiveness characterizes Oppositional Defiant Disorder (ODD). Symptoms must occur over at least six months, involve interactions with individuals beyond siblings, and meet specific diagnostic criteria to be clinically significant. The disorder affects emotional regulation, social interactions, and behavior, often manifesting early in life and influencing long-term development and functioning.
Diagnostic Criteria and...
151