Beta-alanine as a Potential Treatment for Aquagenic Pruritus: An Online Social Media-based Survey Study

Aquagenic pruritus (AP), characterized by intense itching upon water contact, poses a significant challenge for effective treatment, especially in its idiopathic form. This study investigated beta-alanine as a potential therapeutic option for AP.

A comprehensive online survey was conducted among 75 self-reported patients with AP, predominantly Italian, recruited through a dedicated social media group to assess the efficacy and side-effects of beta-alanine supplementation.

Beta-alanine emerged as a prevalent choice among participants, demonstrating promising efficacy with an average relief rating of 8.84 out of 10 (95% CI: 8.52-9.16). The average daily dosage during pruritus exacerbation was 1.59 grams (SD ± 0.73). Transient paresthesia represented the primary side-effect, reported by 39.6% of users.

While further controlled trials are necessary, this anecdotal evidence underscores beta-alanine's potential as a valuable adjunct to AP management, addressing a condition that profoundly impacts quality of life.