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Subanesthetic Dose Ketamine Infusions for Treatment-Resistant Major Depression: An Application Protocol at a Public
Micaela Dines1, Adriana Bulacia2, Paloma Bamondez3
1Sección de Psicopatología y Salud Mental, Departamento de Medicina, Hospital General de Agudos "Dr. Juan A. Fernández". Instituto de Neurociencia Cognitiva y Traslacional (Consejo Nacional de Investigaciones Científicas y Técnicas - Fundación INECO - Universidad Favaloro). Ciudad Autónoma de Buenos Aires, Argentina. . micaeladines.hfer@gmail.com.
Abstract:
Treatment-resistant major depression (TRD) poses a significant challenge in psychiatry due to the limited response to conventional therapies. Subanesthetic dose intravenous (IV) ketamine has emerged as an effective therapeutic option, providing rapid effects on depressive and suicidal symptoms. This article outlines the ketamine infusion protocol implemented in a general hospital, following international guidelines. Inclusion and exclusion criteria, dosage, administration procedure, and patient monitoring. Additionally, adverse effects and safety considerations. The implementation of this protocol optimizes the use of ketamine in TRD, ensuring both efficacy and safety.
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