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Sappanumols A-C, Three Homoisoflavonoids with Antiinflammatory Activities from Sappan lignum
Qi-Qi Wang1, Hao-Jie Liu2, Guo-Qing Qin1
1State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 10019, China.
Abstract:
Sappanumols A-C (1-3, respectively), three unprecedented homoisoflavonoids, were isolated from Sappan lignum. Their structures were elucidated by comprehensive spectroscopic analysis and ECD computation methods. Compound 3 demonstrated inhibitory effects on LPS-induced NO production in BV-2 cells with an IC50 value of 16.99 μM. Compound 3 decreased the levels of TNF-α and IL-6 in a dose-dependent manner and exhibited significant anti-inflammatory activity in a zebrafish inflammation model.
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