Related Experiment Video

Updated: Sep 8, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

1.8K

Association between sickle cell disease and autoimmune diseases in Saudi population: a single center study

Rehab Y Al-Ansari1, Alexander Woodman2, Hana Ibrahim Al Daajani3

  • 1Adult Hematology Unit, Internal Medicine Department, King Fahd Military Medical Complex, Dhahran, Kingdom of Saudi Arabia.

Expert Review of Hematology
|July 14, 2025
PubMed

Insights

Sickle cell disease (SCD) frequently coexists with autoimmune diseases (AID), affecting 15.47% of patients in this study. Common associated AIDs include lupus and hypothyroidism, highlighting the need for screening and early detection in SCD patients.

Area of Science:

  • Hematology
  • Immunology
  • Rheumatology

Background:

  • The relationship between sickle cell disease (SCD) and autoimmune diseases (AID) requires further elucidation.
  • Understanding the co-occurrence of these conditions is crucial for comprehensive patient care.

Purpose of the Study:

  • To investigate the frequency of autoimmune diseases (AID) in patients diagnosed with sickle cell disease (SCD).
  • To identify common autoimmune diseases associated with SCD and their prevalence.

Main Methods:

  • A retrospective analysis of 168 patients with sickle cell disease (SCD) was conducted between January 2016 and March 2023.
  • Data collected included demographics, medications, hospitalization history, SCD phenotypes, presence of AIDs, and laboratory results.

Main Results:

  • 15.47% of SCD patients exhibited coexisting autoimmune diseases (AID), a statistically significant finding (p=0.00001).
  • The most prevalent SCD-associated AIDs were systemic lupus erythematosus (4.2%), hypothyroidism (3.6%), and antiphospholipid syndrome (3.6%).
  • A positive correlation was observed between a higher hospitalization rate and the presence of AID in SCD patients (p=0.03).

Conclusions:

  • This study demonstrates a significant rate of autoimmune disease (AID) co-occurrence in sickle cell disease (SCD) patients.
  • Further research is warranted to establish screening protocols for early detection of AIDs in individuals with SCD.
Abstract

Keywords:
Sickle cell diseaseautoimmune diseaseconnective tissue diseasecytokineshydroxyurea

More Related Videos

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

9.6K
Magnetic Levitation Coupled with Portable Imaging and Analysis for Disease Diagnostics07:42

Magnetic Levitation Coupled with Portable Imaging and Analysis for Disease Diagnostics

Published on: February 19, 2017

8.9K

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
666
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
34.8K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
14.1K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.1K
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
81
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
1.2K