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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Updated: Sep 15, 2025

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Reduced plasma oxytocin levels in patients with open-angle glaucoma.

Yurina Yamada1, Kota Sato2,3, Satoru Tsuda1

  • 1Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan, 980-8574.

Japanese Journal of Ophthalmology
|July 14, 2025
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Summary

Plasma oxytocin levels are significantly lower in glaucoma patients compared to healthy individuals. Lower oxytocin is associated with increased glaucoma severity and progression, suggesting a potential role in the disease.

Keywords:
BiomarkerGlaucomaGlaucoma progressionOxytocin

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Area of Science:

  • Ophthalmology
  • Neuroendocrinology

Background:

  • Glaucoma is a leading cause of irreversible blindness worldwide.
  • Oxytocin, a hormone with diverse physiological roles, has not been extensively studied in the context of glaucoma pathogenesis.

Purpose of the Study:

  • To investigate the association between plasma oxytocin levels and glaucoma.
  • To compare oxytocin concentrations in glaucoma patients versus healthy controls.
  • To examine the correlation between oxytocin levels and clinical parameters of glaucoma severity and progression.

Main Methods:

  • Retrospective cross-sectional study involving 181 glaucoma patients and 44 controls.
  • Plasma oxytocin concentrations were measured using Enzyme Linked Immunosorbent Assay (ELISA).
  • Statistical analyses correlated oxytocin levels with visual field parameters (Mean Deviation, Total Deviation) and their slopes over time.

Main Results:

  • Glaucoma patients exhibited significantly lower plasma oxytocin levels than controls (p=0.002).
  • Oxytocin levels correlated significantly with glaucoma severity (Mean Deviation and inferior Total Deviation).
  • A trend towards negative correlation was observed between oxytocin levels and the rate of visual field defect progression (MD slope and central TD slope).

Conclusions:

  • Reduced plasma oxytocin is linked to glaucoma.
  • Oxytocin levels correlate with the severity and progression of visual field loss in glaucoma.
  • Plasma oxytocin measurement may offer a novel approach for glaucoma management and research.