Liposomes applied in healing bacterially infected wounds: a systematic review

Concerns regarding bacterial infections and antibiotic resistance development have instigated many researchers to synthesize innovative antibacterial compounds and develop more effective pharmaceutical formulations against microorganisms increasingly adapted to our environment. In special, many efforts have been dedicated to developing pharmaceutical antibacterial formulations to treat and improve wound-healing processes, which still represent a great challenge for common clinical practice today. Liposomal systems remain one of the most extensively studied controlled delivery platforms, and considering the antibacterial context, the present article aims to provide a fast and well-oriented systematic review regarding this issue, aiming to bring to the readers the ultimate data regarding the employment of liposomes in the treatment of bacterial infections and the healing of bacteria-infected wounds. A systematic compilation of results and comparisons was made, seeking to observe the antibacterial and wound-healing behavior of the formulated liposomal systems in selected recent studies. The results obtained revealed impressive results concerning the potential applications of liposomes against bacteria in the wound-healing medical context.