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Updated: Sep 15, 2025

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
'Lone Atrial Fibrillation' is a Four Letter Word.
1Professor Emeritus of Medicine, Columbia University Vagelos College of Physicians & Surgeons, New York, NY, USA.
The term "lone atrial fibrillation" (lone AF) is outdated, as modern diagnostics find causes for most AF cases. However, reviewing the "lone AF" era offers valuable clinical insights for practitioners.
Area of Science:
- Cardiology
- Electrophysiology
Background:
- The term "lone atrial fibrillation" (lone AF) historically described AF without a clear cause, seen in up to 30% of patients.
- Modern diagnostic techniques increasingly identify underlying causes for atrial fibrillation.
Purpose of the Study:
- To challenge the current guideline stance against using the term "lone AF".
- To review the clinical relevance of the "lone AF" concept for contemporary medical practice.
Main Methods:
- Review of historical and current literature on atrial fibrillation diagnosis and classification.
- Analysis of the clinical implications of the "lone AF" designation.
Main Results:
- While most AF cases now have identifiable causes, the "lone AF" concept still holds clinical lessons.
- The historical perspective of "lone AF" can aid current practitioners in patient management.
Conclusions:
- The term "lone AF" may be obsolete from a micro-diagnostic standpoint.
- A clinical examination of the "lone AF" era provides valuable insights for current atrial fibrillation management.
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