Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Classification of Bones01:18

Classification of Bones

14.3K
The bones of the human skeletal system are of varied shapes, sizes, and functions. They can be classified based on their shape and function into four major classes: long bones, short bones, flat bones, and irregular bones. Some classifications include a fifth type, the sesamoid bones, as a separate class, whereas others categorize them under short bones.
Long and Short Bones
The appendicular skeleton, particularly the upper and lower limbs, is primarily made of long and short bones. The...
14.3K
General Structure of a Vertebra01:30

General Structure of a Vertebra

7.5K
A typical vertebra, with the exception of the sacrum and coccyx, consists of a body, a vertebral arch, and seven different projections termed processes. The anterior portion of the vertebrae, the body, supports about half the body’s weight. The vertebral bodies progressively increase in size and thickness from the cervical region to the lumbar region of the vertebral column. The intervertebral discs present between the bodies of adjacent vertebrae firmly unites them, forming a continuous...
7.5K
Herniated Intervertebral Disc l: Introduction01:29

Herniated Intervertebral Disc l: Introduction

40
Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
40
Degenerative Disc Disease I: Introduction01:27

Degenerative Disc Disease I: Introduction

29
Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
29
Degenerative Disc Disease ll: Pathophysiology01:23

Degenerative Disc Disease ll: Pathophysiology

30
The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...
30

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tenacibaculum xiamenense sp. nov., an algicidal bacterium isolated from coastal seawater.

International journal of systematic and evolutionary microbiology·2013
Same author

The anchoring protein SAP97 influences the trafficking and localisation of multiple membrane channels.

Biochimica et biophysica acta·2013
Same author

Aegilops tauschii draft genome sequence reveals a gene repertoire for wheat adaptation.

Nature·2013
Same author

Draft genome of the wheat A-genome progenitor Triticum urartu.

Nature·2013
Same author

Citreoviridin enhances tumor necrosis factor-α-induced adhesion of human umbilical vein endothelial cells.

Toxicology and industrial health·2013
Same author

Th17/Treg imbalance induced by increased incidence of atherosclerosis in patients with systemic lupus erythematosus (SLE).

Clinical rheumatology·2013

Related Experiment Video

Updated: May 2, 2026

Ovine Lumbar Intervertebral Disc Degeneration Model Utilizing a Lateral Retroperitoneal Drill Bit Injury
07:25

Ovine Lumbar Intervertebral Disc Degeneration Model Utilizing a Lateral Retroperitoneal Drill Bit Injury

Published on: May 25, 2017

11.7K

A Novel Lumbar Disc Herniation Classification Based on Endplate Destruction.

Hao Tang1, Kai Hu2, Xiao Ma1

  • 1Department of Orthopaedic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China.

World Neurosurgery
|July 14, 2025
PubMed
Summary

A new classification system for lumbar disc herniation based on endplate destruction effectively guides treatment. This system, utilizing machine learning and a nomogram, shows high accuracy in predicting optimal clinical strategies for improved patient outcomes.

Keywords:
Classification systemClinical efficacyEndplate destructionLumbar disc herniationNomogram

More Related Videos

Full-Endoscopic Isolation Zone Technique for the Treatment of Lumbar Disc Herniation
05:42

Full-Endoscopic Isolation Zone Technique for the Treatment of Lumbar Disc Herniation

Published on: April 7, 2023

845
Multilevel Oblique Lumbar Interbody Fusion in Degenerative Lumbar Disc Disease with Instability
11:30

Multilevel Oblique Lumbar Interbody Fusion in Degenerative Lumbar Disc Disease with Instability

Published on: July 25, 2025

574

Related Experiment Videos

Last Updated: May 2, 2026

Ovine Lumbar Intervertebral Disc Degeneration Model Utilizing a Lateral Retroperitoneal Drill Bit Injury
07:25

Ovine Lumbar Intervertebral Disc Degeneration Model Utilizing a Lateral Retroperitoneal Drill Bit Injury

Published on: May 25, 2017

11.7K
Full-Endoscopic Isolation Zone Technique for the Treatment of Lumbar Disc Herniation
05:42

Full-Endoscopic Isolation Zone Technique for the Treatment of Lumbar Disc Herniation

Published on: April 7, 2023

845
Multilevel Oblique Lumbar Interbody Fusion in Degenerative Lumbar Disc Disease with Instability
11:30

Multilevel Oblique Lumbar Interbody Fusion in Degenerative Lumbar Disc Disease with Instability

Published on: July 25, 2025

574

Area of Science:

  • Orthopedics
  • Neurosurgery
  • Medical Imaging

Background:

  • Lumbar disc herniation is a common condition requiring effective treatment strategies.
  • Current classification systems may not fully capture the nuances of endplate destruction in lumbar disc herniation.
  • Guiding clinical decisions for lumbar disc herniation remains a challenge.

Purpose of the Study:

  • To propose a novel classification system for lumbar disc herniation.
  • To base the classification on the degree of endplate destruction.
  • To guide the selection of clinical treatment strategies for lumbar disc herniation.

Main Methods:

  • A cohort of 300 lumbar disc herniation patients was analyzed.
  • Machine learning techniques were employed for variable selection.
  • A nomogram was constructed and validated for predictive accuracy (AUC=0.74).

Main Results:

  • The classification system identified three types (A, B, C) with varying symptom severity.
  • Treatment choices correlated with classification type: Type A favored surgery, Type C favored conservative care.
  • Age and classification were key factors in surgical decision-making.

Conclusions:

  • The novel endplate destruction-based classification system is reliable.
  • This system offers significant reference value for treatment planning in lumbar disc herniation.
  • The classification aids in formulating personalized treatment strategies.