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Updated: Sep 15, 2025
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Using Unidirectional Rotations to Improve Vestibular System Asymmetry in Patients with Vestibular Dysfunction
Published on: August 30, 2019
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Bidirectional Association Between Peripheral Vestibular Disorders and Depressive Disorders: A Longitudinal Follow-Up
Sheue-Jane Hou1, Shun-Chieh Yu2, Shih-Jen Tsai3
1Department of Psychiatry, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City, Taiwan; Department of Psychiatry, Taipei Veterans General Hospital, Taoyuan Branch, Taoyuan, Taiwan.
Summary
Peripheral vestibular disorders (PVDs) and depression show a bidirectional link. PVDs increase depression risk, while depression also elevates the risk of developing PVDs.
Area of Science:
- Neuroscience
- Psychiatry
- Otolaryngology
Background:
- Growing evidence links peripheral vestibular disorders (PVDs) with depressive disorders.
- The temporal and causal relationship between PVDs and depression requires further clarification.
Purpose of the Study:
- To investigate the bidirectional association between peripheral vestibular disorders and depressive disorders.
Main Methods:
- Retrospective cohort study using Taiwan National Health Insurance Research Database (1998-2013).
- Examined PVDs and depressive disorders as both cause and consequence.
- Utilized Cox regression models to assess risk in large patient cohorts (N=87,277 for PVDs, N=87,387 for depression) and controls.
Main Results:
- Patients with PVDs had a 4.29-fold increased risk of developing depression.
- All PVD subtypes (BPPV, Meniere's disease, vestibular neuritis, unspecified PVD) predicted higher depression risks.
- Individuals with depression showed a 3.29-fold increased risk of developing PVDs.
Conclusions:
- A bidirectional relationship exists between PVDs and depression.
- Further research is needed to explore common pathogenic mechanisms.
- Investigate if treating one condition impacts the other's morbidity.
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