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Enhancing cognitive function in breast cancer survivors through community-based aerobic exercise training: protocol
Diane K Ehlers1, Jessica D Austin2, Brenda Ernst3
1Department of Quantitative Health Sciences, Mayo Clinic, Phoenix, Arizona, USA ehlers.diane@mayo.edu.
BMJ Open
|July 14, 2025
Summary
This study investigates if community-based aerobic exercise can improve cognitive function in breast cancer survivors. The Breast cancer Reasoning and Activity INtervention (BRAIN) trial assesses exercise effectiveness and implementation success.
Area of Science:
- Oncology
- Neuroscience
- Exercise Science
Background:
- Cancer-associated cognitive decline (CACD) significantly impacts women with breast cancer.
- Interventions to mitigate CACD are limited, with few high-quality studies on exercise effectiveness.
- Translating exercise interventions to community settings presents implementation challenges.
Purpose of the Study:
- To investigate the effectiveness of a community-based aerobic exercise program for improving cognitive function in women with breast cancer.
- To gather data on the implementation success of the aerobic exercise intervention using the RE-AIM framework.
- To address the understudied outcome of CACD in breast cancer survivors.
Main Methods:
- A Hybrid Type I effectiveness-implementation study with 160 women diagnosed with stage I-IIIa breast cancer.
- 1:1 randomized controlled trial comparing a 6-month aerobic exercise program to a 6-month virtual health education control.
- Cognitive performance, patient-reported outcomes, physical activity, cardiorespiratory fitness, and brain MRI are assessed. Implementation outcomes (RE-AIM) are also measured.
Main Results:
- This section is not available in the provided abstract.
Conclusions:
- This section is not available in the provided abstract.
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