Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electrophysiological Changes in Resting-State EEG Following REAC BWO-G_B Neurobiological Modulation in Healthy Adults: A Spectral and Multivariate Exploratory Study.

Brain sciences·2026
Same author

Correction: Impact of different blood pressure targets on cerebral hemodynamics in septic shock: A prospective pilot study protocol-SEPSIS-BRAIN.

PloS one·2026
Same author

Impaired Intracranial Compliance: A New Hypertension-Mediated Brain Organ Damage?

High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension·2026
Same author

The clinical significance of intracranial pressure waveform analysis in brain-injured patients.

Critical care science·2026
Same author

A noninvasive method for assessing optimal cerebral perfusion pressure.

Critical care (London, England)·2026
Same author

Correction: Exploring Cerebrospinal Compensatory Zones Using a Noninvasive Approach.

Neurocritical care·2026

Related Experiment Video

Updated: Sep 15, 2025

A Bedside, Single Burr Hole Approach to Multimodality Monitoring in Severe Brain Injury
06:18

A Bedside, Single Burr Hole Approach to Multimodality Monitoring in Severe Brain Injury

Published on: March 26, 2019

9.1K

Exploring Cerebrospinal Compensatory Zones Using a Noninvasive Approach.

Sérgio Brasil1, Marek Czosnyka2, Wellingson S Paiva3

  • 1Division of Neurosurgery, Department of Neurology, University of São Paulo Medical School, São Paulo, Brazil. sbrasil@alumni.usp.br.

Neurocritical Care
|July 14, 2025
PubMed
Summary

Noninvasive intracranial compliance (ICC) monitoring using P2/P1 ratio and time-to-peak (TTP) shows significant correlation with invasive RAP index. This may allow earlier intervention in neurocritical care.

Keywords:
Acute brain injuryCerebral arterial blood volumeCerebrospinal complianceIntracranial pressureNoninvasive neuromonitoring

More Related Videos

Author Spotlight: Stimulation-Based Approach to Improve Cerebral Blood Flow in Alzheimer's Model
06:34

Author Spotlight: Stimulation-Based Approach to Improve Cerebral Blood Flow in Alzheimer's Model

Published on: June 2, 2023

1.3K
Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression
11:26

Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression

Published on: December 10, 2014

12.5K

Related Experiment Videos

Last Updated: Sep 15, 2025

A Bedside, Single Burr Hole Approach to Multimodality Monitoring in Severe Brain Injury
06:18

A Bedside, Single Burr Hole Approach to Multimodality Monitoring in Severe Brain Injury

Published on: March 26, 2019

9.1K
Author Spotlight: Stimulation-Based Approach to Improve Cerebral Blood Flow in Alzheimer's Model
06:34

Author Spotlight: Stimulation-Based Approach to Improve Cerebral Blood Flow in Alzheimer's Model

Published on: June 2, 2023

1.3K
Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression
11:26

Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression

Published on: December 10, 2014

12.5K

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Critical Care Medicine

Background:

  • Intracranial compliance (ICC) is crucial for balancing intracranial volume components.
  • Technological advancements allow continuous, noninvasive ICC assessment in neurocritical care.
  • This study correlates noninvasive ICC parameters with the invasive Amplitude-Pressure Index (RAP index).

Purpose of the Study:

  • To correlate noninvasive ICC parameters derived from intracranial pressure (ICP) waveform morphology with the established RAP index.
  • To evaluate the potential of noninvasive ICP waveform analysis for assessing ICC status.
  • To explore earlier intervention strategies in neurocritical care based on noninvasive ICC monitoring.

Main Methods:

  • Patients with traumatic brain injury underwent invasive ICP monitoring (ventricular catheter).
  • Simultaneously, ICP waveform characteristics were recorded using a noninvasive external skull microdynamics sensor (brain4care).
  • Noninvasive parameters (P2/P1 ratio, time-to-peak) were analyzed against RAP index-based ICC classifications (adequate, compromised, exhausted).

Main Results:

  • A total of 61 patients were included in the study.
  • Significant associations were found between noninvasive parameters (P2/P1 ratio, TTP) and RAP index-based ICC classification (p < 0.0001).
  • A critical ICP cut-off of 19.45 mmHg was identified, below current TBI guideline thresholds.

Conclusions:

  • Noninvasive ICP waveform parameters (P2/P1 ratio, TTP) significantly correlate with the invasive RAP index.
  • These noninvasive measures show potential as reliable indicators of intracranial compliance status.
  • This approach may facilitate earlier intervention and noninvasive monitoring in neurocritical care, potentially improving patient outcomes.