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The Combination of Natural Products: A Promising Therapeutical Way for Management of Breast Cancers

Pei-Pei Wang1,2, Cheng-Xun He1, Yang-Yang Shuai1

  • 1State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.

Phytotherapy Research : PTR
|July 15, 2025
PubMed

Insights

Natural products combined with chemotherapy show promise for breast cancer treatment by targeting multiple cancer pathways. Further clinical trials are needed to confirm their effectiveness and safety in patients.

Area of Science:

  • Oncology
  • Pharmacology
  • Natural Products Research

Background:

  • Breast cancer is the most common gynecological malignancy globally.
  • Natural products have a history in antiviral therapies and show potential in breast cancer management.
  • Combinatorial approaches with natural products offer unique therapeutic advantages.

Purpose of the Study:

  • To review recent advances in the therapeutic effectiveness of natural product combination therapy for breast cancer.
  • To elucidate the underlying mechanisms of these combinations.
  • To explore their potential in modulating the tumor microenvironment and immune responses.

Main Methods:

  • Review of recent scientific literature on natural product combination therapy in breast cancer.
  • Analysis of studies investigating mechanisms of action.
  • Examination of preclinical and clinical data.

Main Results:

  • Natural product combinations target multiple oncogenic pathways, including proliferation, viability, autophagy, angiogenesis, invasion, metastasis, cell cycle, and apoptosis.
  • These combinations can modulate immune responses and remodel the tumor microenvironment.
  • Evidence suggests broad anticancer effects beyond direct cytotoxicity.

Conclusions:

  • Natural product combination therapy presents a promising strategy for breast cancer treatment.
  • These combinations offer multifaceted anticancer effects and immunomodulatory potential.
  • Rigorous clinical trials are essential to validate the efficacy of natural product-chemotherapeutic combinations.
Keywords:
breast cancercombination usenatural productsynergistic effect

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