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Published on: September 13, 2014
Hepatitis patients undergoing cardiac surgery: A single-center retrospective study
Jin-Long Ju1, Yun-Tai Yao2,3,4, Jun Li5
1Department of Anesthesiology, Sichuan Science City Hospital, Mianyang, China.
Insights
This study found no significant difference in blood loss during cardiac surgery between patients with hepatitis B and hepatitis C. However, hepatitis C patients showed lower intraoperative hematocrit and a higher need for red blood cell transfusions.
Area of Science:
- Cardiology
- Hepatology
- Transfusion Medicine
Background:
- Cardiac surgery in patients with hepatitis requires careful management of clinical variables.
- Understanding differences in outcomes between hepatitis B and C patients is crucial for surgical planning.
Purpose of the Study:
- To compare clinical outcomes, particularly blood loss and drainage volume, in patients with hepatitis B versus hepatitis C undergoing cardiac surgery.
- To identify potential differences in transfusion requirements and organ function between the two hepatitis groups.
Main Methods:
- Retrospective analysis of 150 hepatitis patients (127 hepatitis B, 23 hepatitis C) who underwent cardiac surgery.
- Collected and statistically analyzed preoperative, intraoperative, and postoperative variables.
- Assessed differences in blood loss, drainage volume, transfusion rates, vasoactive drug use, and hepatic/renal function.
Main Results:
- No significant difference in intraoperative or total postoperative blood loss between hepatitis B and C groups.
- Hepatitis C patients had significantly lower minimum intraoperative hematocrit (P=.01).
- Hepatitis C patients showed a significantly higher proportion requiring red blood cell (RBC) transfusion (P=.043).
Conclusions:
- Hepatitis C patients undergoing cardiac surgery experience lower intraoperative hematocrit and increased need for RBC transfusions compared to hepatitis B patients.
- Overall blood loss is not significantly associated with hepatitis type in this cohort.
- Further research may be warranted to explore the underlying reasons for transfusion differences.
Abstract:
This study aimed to investigate whether there is difference among various clinical variables, especially blood loss and total drainage volume, among patients with different types of hepatitis undergoing cardiac surgery. A retrospective study was performed on 150 hepatitis patients (127 hepatitis B and 23 hepatitis C) who underwent cardiac surgery at a single cardiovascular center in 2020. Data on their preoperative, intraoperative, and postoperative variables were collected and statistically analyzed to assess the inter-group differences in the following variables: intraoperative blood loss, postoperative drainage volume, proportion of patients treated with blood transfusion, proportion of patients treated with vasoactive drugs, and changes in hepatic and renal function. In terms of the main outcome variables, there was no significant difference with respect to intraoperative blood loss and total postoperative blood loss between the 2 groups (P > .05). The lowest intraoperative hematocrit (HCT) was (26.43 ± 4.98)% and (23.5 ± 3.94)% in the hepatitis B and C groups; a significant difference was observed (P = .01). The proportion of patients requiring red blood cell (RBC) transfusion was 3.90% and 17.40% in the hepatitis B and C groups; a significant difference was also noted (P = .043). Hepatitis C patients had a lower intraoperative minimum HCT and a higher probability of RBC transfusion than hepatitis B patients undergoing cardiac surgery. However, blood loss and the total postoperative blood loss were not found to be associated with any specific type of hepatitis.
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