Diffuse Large B-Cell Lymphoma with Cardiac Metastasis: A Case Report.

Area of Science:

• Oncology
• Cardiology

Background:

• Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin's lymphoma (NHL).
• Cardiac metastasis in DLBCL is rare but carries significant risks, including heart rupture and arrest.
• Non-specific symptoms can delay diagnosis of DLBCL, complicating management.

Purpose of the Study:

• To report a rare case of DLBCL with cardiac and multiorgan metastases.
• To discuss the diagnostic and therapeutic challenges associated with cardiac DLBCL.
• To emphasize the importance of cardiac function monitoring during chemotherapy.

Main Methods:

• A 63-year-old female patient presented with abdominal symptoms.
• Diagnosis was confirmed via contrast-enhanced CT and pathology biopsy, revealing DLBCL with cardiac and systemic metastases.
• Initial treatment with R-CHOP was modified to R-CEOD due to severe bradycardia.

Main Results:

• The patient achieved a partial response (PR) after 3 cycles of R-CEOD chemotherapy.
• Close monitoring revealed severe bradycardia, requiring treatment regimen adjustment.
• Cardiac function was assessed using echocardiography, electrocardiogram, and brain natriuretic peptide levels.

Conclusions:

• Anthracycline-based chemotherapy is preferred for DLBCL with cardiac metastasis.
• Proactive cardiac function assessment and vigilant monitoring for cardiotoxicity are crucial during treatment.
• Prompt management of chemotherapy-induced cardiac adverse events is essential for patient outcomes.