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Updated: Sep 15, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

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Copper death combination therapy: the innovative frontier and challenges in prostate cancer treatment

Jia Wei He1, Pei Zhen Li2, Zi Xuan Huang1

  • 1Department of Urology, Dongguan Songshan Lake Central Hospital, Dongguan, China.

Cancer Biology & Therapy
|July 15, 2025
PubMed

Insights

Cuproptosis, a cell death process involving copper, shows promise for treating prostate cancer (PCA). Research explores copper

Area of Science:

  • Oncology and Molecular Biology
  • Investigating novel cell death pathways in cancer therapy

Background:

  • Prostate cancer (PCA) presents a significant therapeutic challenge.
  • Elevated copper levels are linked to PCA progression and treatment resistance.
  • Cuproptosis, a copper-dependent programmed cell death, emerges as a potential therapeutic target.

Purpose of the Study:

  • To review the current understanding of copper and cuproptosis in prostate cancer.
  • To explore the mechanisms, biomarkers, and therapeutic potential of targeting cuproptosis in PCA.

Main Methods:

  • Literature review synthesizing current research on copper metabolism and cuproptosis in PCA.
  • Analysis of mechanisms, biomarkers, and therapeutic strategies involving copper complexes and ionophores.

Main Results:

  • Cuproptosis is identified as a key mechanism influenced by copper levels in PCA.
  • Biomarkers related to cuproptosis could enable personalized PCA treatment strategies.
  • Copper-based therapies offer a potential alternative to traditional chemotherapy for PCA.

Conclusions:

  • Cuproptosis represents a promising therapeutic avenue for prostate cancer.
  • Further research into molecular mechanisms and therapeutic optimization is crucial.
  • Targeting copper metabolism and cuproptosis may improve PCA patient outcomes.
Keywords:
Prostate cancerandrogen receptorcopper metabolismdrug resistancetherapeutic strategies

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