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Updated: Sep 15, 2025
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Recurrent Systemic Embolization in a Patient With Aortic Valve Amyloidosis
Annalisa Caputo1, Amedeo Pergolini2, Luigi Monticelli3
1Department of Cardiovascular and Respiratory Science, Sapienza University of Rome, Rome, Italy.
Echocardiography (Mount Kisco, N.Y.)
|July 15, 2025
Summary
A rare case highlights aortic valve thrombosis due to isolated aortic valve amyloidosis in a patient with antiphospholipid syndrome. This rare condition led to recurrent thromboembolic events, including STEMI and limb ischemia.
Area of Science:
- Cardiology
- Hematology
- Pathology
Background:
- Antiphospholipid syndrome (APS) is an autoimmune disorder associated with an increased risk of thrombosis.
- Aortic valve amyloidosis is a rare condition characterized by the deposition of amyloid protein in the aortic valve.
Observation:
- A 47-year-old woman presented with recurrent thromboembolic events, including ST-elevation myocardial infarction (STEMI) and lower limb ischemia.
- Diagnostic workup revealed aortic valve thrombosis.
Findings:
- The aortic valve thrombosis was attributed to isolated aortic valve amyloidosis.
- The patient had overlapping antiphospholipid syndrome, complicating the clinical picture.
Implications:
- This case underscores the importance of considering rare causes of aortic valve thrombosis in patients with recurrent thromboembolic events and APS.
- Early diagnosis and management are crucial to prevent severe cardiovascular complications.
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