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Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...

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Piscine-Derived Acellular Dermal Matrix in Upper Extremity Reconstruction.

Shawhin Shahriari1,2, Cees Whisonant3, Joseph Kuhn1

  • 1University of New Mexico, Department of Surgery, Division of Plastic, Reconstructive, Hand and Burn Surgery, Albuquerque, New Mexico.

Eplasty
|July 15, 2025
PubMed
Summary

The Kerecis Omega3 Wound, a piscine acellular dermal matrix (ADM), effectively reconstructs upper extremity wounds with exposed critical structures. This advanced wound care solution promotes biologic integration and allows for early patient discharge and outpatient management.

Keywords:
Acellular Dermal MatrixFish SkinKerecisLimb SalvageUpper Extremity Salvage

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Plastic Surgery

Background:

  • Wound reconstruction with exposed critical structures poses challenges, especially in high-risk patients.
  • Acellular dermal matrices (ADMs) improve the management of complex wounds.
  • Piscine ADM (Kerecis Omega3 Wound) shows potential for chronic wound and burn treatment.

Purpose of the Study:

  • To evaluate the efficacy of the Kerecis Omega3 Wound for upper extremity wound reconstruction.
  • To assess outcomes in patients with exposed critical structures requiring wound coverage.

Main Methods:

  • A consecutive case series of 11 patients with upper extremity wounds treated from 2019 to 2021.
  • Inclusion of 9 patients with exposed critical structures.
  • Tabulation of clinical data to assess wound healing and patient outcomes.

Main Results:

  • The Kerecis Omega3 Wound incorporated within 2 weeks, facilitating granulation tissue coverage of vital structures.
  • Average time to discharge was 6 days, with 3 patients discharged same-day.
  • Skin grafting was successfully performed as an outpatient procedure after an average of 3 weeks.

Conclusions:

  • The Kerecis Omega3 Wound enables complete biologic integration and vascularized coverage, accepting skin grafts.
  • This ADM allows for early discharge and outpatient follow-up, improving patient management.
  • It is a safe and well-tolerated option for complex upper extremity wounds, including in diabetic and immunocompromised patients.