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Causal relationship between asthma and ankylosing spondylitis: A bidirectional two-sample univariable and
Yiming Yao1, Shiqiang Zhou1, Yumin Fang1
1Department of Respiratory and Critical Care Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, 510000, China.
Open Medicine (Warsaw, Poland)
|July 15, 2025
Summary
Asthma, particularly eosinophilic asthma, increases the risk of developing ankylosing spondylitis (AS). This Mendelian randomization study confirms a causal link between asthma and AS, highlighting the need for further investigation into this association.
Area of Science:
- Genetics
- Immunology
- Rheumatology
Background:
- Emerging evidence suggests a potential link between asthma and ankylosing spondylitis (AS).
- Understanding this relationship is crucial for comprehensive patient care and disease management.
Purpose of the Study:
- To investigate the potential causal relationship between asthma and ankylosing spondylitis (AS).
- To explore specific asthma phenotypes associated with an increased risk of AS.
Main Methods:
- Utilized a bidirectional two-sample Mendelian randomization (TSMR) analysis with single nucleotide polymorphisms (SNPs) as instrumental variables.
- Focused on European populations to minimize racial confounding and performed multivariate adjustments for BMI, smoking, and alcohol use.
- Employed colocalization analysis to validate findings and explore genetic links.
Main Results:
- Asthma and eosinophilic asthma were associated with a significantly higher risk of AS.
- No causal relationship was found between allergic asthma, childhood-onset asthma, or obesity-related asthma and AS.
- After adjusting for confounders, a direct causal effect of asthma on AS onset was confirmed (IVW P = 0.001).
Conclusions:
- Confirmed a positive causal association between asthma, specifically eosinophilic asthma, and ankylosing spondylitis.
- Findings underscore the importance of considering respiratory health in AS risk assessment.
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