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  11. The Genoa Vascular Biobank: A Today Resource For Future Perspectives In Vascular Research

The Genoa Vascular Biobank: A Today Resource for Future Perspectives in Vascular Research

Chiara Barisione1,2,3, Jorge Miguel Mena Vera4, Caterina Ivaldo1

  • 1Department of Surgical and Integrated Diagnostic Sciences, University of Genoa, Genoa, Italy.

Biomarker Insights
|July 15, 2025

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View abstract on PubMed

Summary
This summary is machine-generated.

The Genoa Vascular Biobank (GTB-VD) collects biospecimens and clinical data from patients with carotid artery stenosis (CS) and abdominal aortic aneurysm (AAA). This biobank supports research into arteriopathies, aiming to develop new prevention and treatment strategies.

Area of Science:

  • Vascular Biology and Medicine
  • Biobanking and Data Science
  • Genomics and Precision Medicine

Background:

  • Advancements in big data and -omics sciences necessitate high-quality biospecimen and data for improved biological knowledge and patient care.
  • Biobanks are crucial dynamic units designed to meet these stringent requirements for research and clinical applications.
  • The Genoa Vascular Biobank (GTB-VD) exemplifies a collaborative network dedicated to high-standard biospecimen and data collection.

Purpose of the Study:

  • To describe the workflow, ethical, and governance frameworks of the Genoa Vascular Biobank (GTB-VD).
  • To detail the demographic and clinical characteristics of patients enrolled in the GTB-VD.
  • To report on the volume of open and endovascular surgical interventions associated with collected samples.

Main Methods:

Keywords:
Vascular surgeryabdominal aortic aneurysmcarotid artery stenosisvascular biobank workflow

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  • The GTB-VD recruits patients undergoing surgical repair for carotid artery stenosis (CS) and abdominal aortic aneurysm (AAA).
  • Biospecimens include serum, plasma, whole blood, PBMCs, and urine, stored at -80°C, with lesions also cryopreserved or formalin-fixed and paraffin-embedded.
  • Clinical data are pseudonymized and linked to samples, with quality ensured by harmonized standard operating procedures.

Main Results:

  • Between 2018 and 2023, 442 CS and 214 AAA cases were collected.
  • CS cases showed a 5:1 ratio of severe-asymptomatic to symptomatic, frequently associated with diabetes and peripheral artery diseases.
  • AAA cases were more commonly linked to pulmonary history and renal impairment, with endovascular surgery being the preferred approach.

Conclusions:

  • The GTB-VD is a unique resource in Italy, supporting research into molecular targets and biomarkers for arteriopathies.
  • The biobank aims to facilitate the development of secondary prevention strategies and novel therapeutic interventions.
  • Collaborative research initiatives and sample sharing are encouraged to advance vascular disease understanding and treatment.