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Cardiovascular disease risk and Lung cancer screening for Early Assessment of Risk (project CLEAR) in Missouri: A protocol for a mixed methods study

  • 0Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Medrxiv : the Preprint Server for Health Sciences +

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July 15, 2025

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July 15, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Lung cancer screening patients often miss statin prescriptions for atherosclerotic cardiovascular disease (ASCVD) prevention. This study examines real-world statin use, eligibility, and barriers in Missouri LCS programs.

Area Of Science

  • Cardiology
  • Pulmonology
  • Public Health

Background

  • Lung cancer and atherosclerotic cardiovascular disease (ASCVD) are leading causes of mortality.
  • Shared risk factors include smoking and age, yet preventive care is often siloed.
  • ASCVD mortality is a significant concern for patients undergoing lung cancer screening (LCS).

Purpose Of The Study

  • To assess ASCVD risk assessment and prevention in real-world LCS settings in Missouri.
  • To determine the prevalence of statin eligibility and prescription among LCS patients.
  • To explore factors, disparities, and barriers affecting statin therapy in this population.

Main Methods

  • A parallel convergent mixed-methods design.
  • Quantitative analysis of ~8,000 electronic medical records (EMR) from January 2022-December 2023.
  • Qualitative interviews with up to 15 healthcare providers to identify barriers and facilitators.

Main Results

  • Data on statin eligibility, prescription rates, and associated factors will be presented.
  • Insights into disparities and barriers to statin therapy will be identified.
  • Real-world baseline data on statin use in LCS patients will be established.

Conclusions

  • Integrating ASCVD risk assessment and prevention into LCS programs can mitigate dual mortality risks.
  • Addressing the gap in statin therapy is crucial for high-risk populations.
  • Study findings will inform recommendations for enhanced ASCVD prevention within LCS programs.

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