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Updated: Sep 15, 2025

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
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Sequential Membrane Remodeling by Cholesterol Distinctly Modulates HCN Channels in Naïve and Neuropathic DRG Neurons

Lucas J Handlin, Clémence Gieré, Nicolas L A Dumaire

    Biorxiv : the Preprint Server for Biology
    |July 15, 2025
    PubMed
    Summary

    Cholesterol modulates hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in dorsal root ganglion (DRG) neurons, impacting neuropathic pain. Membrane remodeling and cholesterol levels influence HCN channel function differently in injured versus healthy neurons.

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