Primary tumor microbiomes predict distant metastasis of colorectal cancer
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View abstract on PubMed
Summary
This summary is machine-generated.Primary tumor microbiome composition can predict colorectal cancer (CRC) metastasis. Specific bacteria like B. fragilis and E. coli are linked to metastasis risk, offering potential prognostic markers.
Area Of Science
- Oncology
- Microbiome Research
- Genomics
Background
- Metastasis is the primary cause of colorectal cancer (CRC) mortality.
- Microbiome alterations in primary tumors may hold prognostic significance for CRC metastasis.
Purpose Of The Study
- To investigate the predictive value of primary tumor microbiomes for distant CRC metastasis.
- To identify specific microbial signatures associated with metastasis-free survival.
Main Methods
- Retrospective analysis of 900 CRC tumor microbiomes (RNAseq) from the ORIEN cohort.
- Validation using 16S rDNA sequencing and pathobiont-specific qPCR in an independent cohort.
- Assessment of microbiome alpha and beta diversity, and microbial co-occurrence patterns.
Main Results
- Microbiome alpha diversity was higher in primary tumors and correlated with metastasis risk.
- Microbiome beta diversity differentiated primary tumors from metastases and predicted 5-year metastasis-free survival.
- Specific bacteria, including high B. fragilis and low F. nucleatum, and enriched Enterobacteriaceae (E. coli) in metastases, were associated with MFS. Enterotoxigenic B. fragilis and pks+ E. coli were increased in metastasizers. A 3-species microbial clique predicted metastasis (OR 1.9).
Conclusions
- Primary tumor microbiomes serve as precision markers for colorectal cancer metastasis risk.
- Specific pathobionts and their abundance patterns are key indicators for predicting CRC metastasis.
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