Related Experiment Video

Updated: Sep 15, 2025

Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes
11:33

Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes

Published on: March 12, 2013

13.5K

Mechanisms of KCNQ1 gating modulation by KCNE1/3 for cell-specific function

Chenxi Cui, Lu Zhao, Ali A Kermani

    Biorxiv : the Preprint Server for Biology
    |July 15, 2025
    PubMed
    Summary

    KCNE1 and KCNE3 subunits distinctly regulate KCNQ1 potassium channels via two PIP2-binding sites, influencing voltage sensitivity and gating for tissue-specific ion homeostasis.

    More Related Videos

    Patch Clamp and Perfusion Techniques for Studying Ion Channels Expressed in Xenopus oocytes10:19

    Patch Clamp and Perfusion Techniques for Studying Ion Channels Expressed in Xenopus oocytes

    Published on: January 10, 2011

    21.2K
    Recapitulation of an Ion Channel IV Curve Using Frequency Components10:14

    Recapitulation of an Ion Channel IV Curve Using Frequency Components

    Published on: February 8, 2011

    13.6K

    Related Concept Videos

    The Role of Ion Channels in Neuronal Computation01:19

    The Role of Ion Channels in Neuronal Computation

    A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
    Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
    3.3K
    Non-gated Ion Channels01:24

    Non-gated Ion Channels

    Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
    Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
    7.1K
    Mechanically-gated Ion Channels01:12

    Mechanically-gated Ion Channels

    Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
    6.7K
    Voltage-gated Ion Channels01:26

    Voltage-gated Ion Channels

    Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
    Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several...
    8.6K
    Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

    Ligand-Gated Ion Channel Receptor: Gating Mechanism

    Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
    2.6K
    G-Protein Gated Ion Channels01:21

    G-Protein Gated Ion Channels

    GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
    Sensory...
    4.8K